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Lactase persistence

MedGen UID:
347396
•Concept ID:
C1857231
•
Finding
Synonym: LACTASE PERSISTENCE
 
OMIM®: 223100; 601806

Professional guidelines

PubMed

Genetics of Lactose Intolerance: An Updated Review and Online Interactive World Maps of Phenotype and Genotype Frequencies.
Anguita-Ruiz A, Aguilera CM, Gil Á
Nutrients 2020 Sep 3;12(9) doi: 10.3390/nu12092689. PMID: 32899182Free PMC Article
Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management.
Misselwitz B, Butter M, Verbeke K, Fox MR
Gut 2019 Nov;68(11):2080-2091. Epub 2019 Aug 19 doi: 10.1136/gutjnl-2019-318404. PMID: 31427404Free PMC Article
Lactose intolerance: from diagnosis to correct management.
Di Rienzo T, D'Angelo G, D'Aversa F, Campanale MC, Cesario V, Montalto M, Gasbarrini A, Ojetti V
Eur Rev Med Pharmacol Sci 2013;17 Suppl 2:18-25. PMID: 24443063

Recent clinical studies

Therapy

Gene-Dairy Food Interactions and Health Outcomes: A Review of Nutrigenetic Studies.
Comerford KB, Pasin G
Nutrients 2017 Jul 6;9(7) doi: 10.3390/nu9070710. PMID: 28684688Free PMC Article
Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.
Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L; CHARGE Consortium
BMJ 2017 Mar 16;356:j1000. doi: 10.1136/bmj.j1000. PMID: 28302601Free PMC Article
Lactose nutrition in lactase nonpersisters.
Wahlqvist ML
Asia Pac J Clin Nutr 2015;24 Suppl 1:S21-5. doi: 10.6133/apjcn.2015.24.s1.04. PMID: 26715080
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.
Amiri M, Diekmann L, von Köckritz-Blickwede M, Naim HY
Nutrients 2015 Aug 28;7(9):7209-30. doi: 10.3390/nu7095332. PMID: 26343715Free PMC Article
Lactose intolerance: from diagnosis to correct management.
Di Rienzo T, D'Angelo G, D'Aversa F, Campanale MC, Cesario V, Montalto M, Gasbarrini A, Ojetti V
Eur Rev Med Pharmacol Sci 2013;17 Suppl 2:18-25. PMID: 24443063

Prognosis

White as milk: Biocentric bias in the framing of lactose intolerance and lactase persistence.
Kaufman EJ, Tan C
Sociol Health Illn 2022 Nov;44(9):1533-1550. Epub 2022 Aug 26 doi: 10.1111/1467-9566.13528. PMID: 36018892
Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.
Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB
Sci Rep 2018 Apr 4;8(1):5649. doi: 10.1038/s41598-018-23957-4. PMID: 29618745Free PMC Article
Lactase persistence, milk intake, and mortality in the Danish general population: a Mendelian randomization study.
Bergholdt HKM, Nordestgaard BG, Varbo A, Ellervik C
Eur J Epidemiol 2018 Feb;33(2):171-181. Epub 2017 Oct 25 doi: 10.1007/s10654-017-0328-x. PMID: 29071499
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.
Amiri M, Diekmann L, von Köckritz-Blickwede M, Naim HY
Nutrients 2015 Aug 28;7(9):7209-30. doi: 10.3390/nu7095332. PMID: 26343715Free PMC Article
Lactose intolerance: from diagnosis to correct management.
Di Rienzo T, D'Angelo G, D'Aversa F, Campanale MC, Cesario V, Montalto M, Gasbarrini A, Ojetti V
Eur Rev Med Pharmacol Sci 2013;17 Suppl 2:18-25. PMID: 24443063

Clinical prediction guides

The selection landscape and genetic legacy of ancient Eurasians.
Irving-Pease EK, Refoyo-Martínez A, Barrie W, Ingason A, Pearson A, Fischer A, Sjögren KG, Halgren AS, Macleod R, Demeter F, Henriksen RA, Vimala T, McColl H, Vaughn AH, Speidel L, Stern AJ, Scorrano G, Ramsøe A, Schork AJ, Rosengren A, Zhao L, Kristiansen K, Iversen AKN, Fugger L, Sudmant PH, Lawson DJ, Durbin R, Korneliussen T, Werge T, Allentoft ME, Sikora M, Nielsen R, Racimo F, Willerslev E
Nature 2024 Jan;625(7994):312-320. Epub 2024 Jan 10 doi: 10.1038/s41586-023-06705-1. PMID: 38200293Free PMC Article
Genetic history of the African Sahelian populations.
Černý V, Kulichová I, Poloni ES, Nunes JM, Pereira L, Mayor A, Sanchez-Mazas A
HLA 2018 Mar;91(3):153-166. Epub 2018 Jan 16 doi: 10.1111/tan.13189. PMID: 29215793
Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis.
Storhaug CL, Fosse SK, Fadnes LT
Lancet Gastroenterol Hepatol 2017 Oct;2(10):738-746. Epub 2017 Jul 7 doi: 10.1016/S2468-1253(17)30154-1. PMID: 28690131
Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.
Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L; CHARGE Consortium
BMJ 2017 Mar 16;356:j1000. doi: 10.1136/bmj.j1000. PMID: 28302601Free PMC Article
Lactose intolerance: from diagnosis to correct management.
Di Rienzo T, D'Angelo G, D'Aversa F, Campanale MC, Cesario V, Montalto M, Gasbarrini A, Ojetti V
Eur Rev Med Pharmacol Sci 2013;17 Suppl 2:18-25. PMID: 24443063

Recent systematic reviews

Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis.
Storhaug CL, Fosse SK, Fadnes LT
Lancet Gastroenterol Hepatol 2017 Oct;2(10):738-746. Epub 2017 Jul 7 doi: 10.1016/S2468-1253(17)30154-1. PMID: 28690131
Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.
Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L; CHARGE Consortium
BMJ 2017 Mar 16;356:j1000. doi: 10.1136/bmj.j1000. PMID: 28302601Free PMC Article
Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis.
Hartwig FP, Horta BL, Smith GD, de Mola CL, Victora CG
Int J Epidemiol 2016 Oct;45(5):1573-1587. Epub 2016 May 11 doi: 10.1093/ije/dyw074. PMID: 27170764Free PMC Article

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